Publications

204. Martinez C, Uranga-Ocio, Pecanha FM, Vassallo DV, Exley C, Miguel-Castro & Wiggers GA (2022) Dietary Egg White Hydrolysate Prevents Male Reproductive Dysfunction after Long-Term Exposure to Aluminum in Rats. Metabolites. 12(12), 1188. https://doi.org/10.3390/metabo12121188.

203. Shardlow E, Brown L & Exley C (2022) The influence of aluminium and copper upon the early aggregator behaviour and size of Islet amyloid polypeptide under simulated
physiological conditions. Journal of Trace Elements in Medicine and Biology. 73, 127027, doi: https://doi.org/10.1016/j.jtemb.2022.127027.

202. Mold M & Exley C (2022) Aluminium co-localises with Biondi ring tangles in Parkinson's disease and epilepsy. Scientific Reports. 12, 1465, doi: https://doi.org/10.1038/s41598-022-05627-8.

201. Shardlow E, Khan B & Exley C (2021) Monitoring the early aggregator behaviour and size of Abeta1-42 in the absence & presence of metal ions using dynamic light scattering. Journal of Trace Elements in Medicine and Biology. 67, 126766, doi: 10.1016/j.jtemb.2021.126766

200. Shardlow E, Linhart C, Connor S, Softely E & Exley C (2021) The measurement and full statistical analysis including Bayesian methods of the aluminium content of infant vaccines. Journal of Trace Elements in Medicine and Biology. 66, 126762, doi: 10.1016/j.jtemb.2021.126762.

199. Mold MJ, O'Farrell A, Morris B, & Exley C (2021) Aluminum and tau in neurofibrillary tangles in familial Alzheimer's disease. Journal of Alzheimer's Disease Reports. 5, 283-294, doi: 10.3233/ADR-210011.

198. Crivelli SM, Luo Q, Stevens JAA, Giovagnoni C, van Kruining D, Bode G, den Hoedt S, Hobo B, Scheithauer A, Walter J, Mulder MT, Exley C, Mold M, Mielke MM, De Vries HE, Wouters K, van den Hove A, Berkes D, Ledesma MD, Verhaagen J, Losen M, Bieberich E & Martinez-Martinez P (2021) CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease. Alzheimer’s Research & Therapy. 13, 45. doi: 10.1186/s13195-021-00780-0.

197. Mold MJ, O'Farrell A, Morris B & Exley C (2020) Aluminium and neurofibrillary tangle co-localisation in familial Alzheimer's disease and related neurological disorders. Journal of Alzheimer's disease. 78, 139-149, doi: 10.3233/JAD-200838.

196. Crépeaux G, Authier FJ, Exley C, Luján L & Gherardi R (2020) The role of aluminium adjuvants in vaccines raises issues that deserve independent, rigorous and honest science. Journal of Trace Elements in Medicine and Biology, 62: 126632, doi: 10.1016/j.jtemb.2020.126632.

195. Shardlow E, Mold M & Exley C (2020) RE: Nies I, Hidalgo K, Bondy SC, Campbell A. Distinctive cellular response to aluminium based adjuvants. Environmental Toxicology and Pharmacology, 103404; 79, 103435, doi: 10.1016/j.etap.2020.103435.

194. Reichert KP, Pillat MM, Schetinger MRC, Bottari NB, Palma TV, Assmann CE, Gutierres JM, Ulrich H, Andrade CM, Exley C& Morsch VMM (2020) Aluminum-induced alterations of purinergic signalling in embryonic neural progenitor cells. Chemosphere, 251, doi:10.1016/j.chemosphere.2020.126642.

193. Exley C (2020) Aluminium-based fluid warmers are not proven to be safe. Anaesthesia, 75, 833-833, doi: 10.1111/anae.15013.

192. Exley C & Clarkson E (2020) Aluminium in human brain tissue from donors without neurodegenerative disease: A comparison with Alzheimer's disease, multiple sclerosis and autism. Scientific Reports, 10, 7770, doi: 10.1038/s41598-020-64734-6.

191. Guerriero G, Stokes I, Valle N, Hausman JF & Exley C (2020) Visualising silicon in plants: Histochemistry, silica sculptures and elemental imaging. Cells, 9(4), 1066, doi: 10.3390/cells9041066.

190. Exley C & Mold M (2020) Imaging of aluminium and amyloid ß in neurodegenerative disease. Heliyon, 6, e03839, doi: 10.1016/j.heliyon.2020.e03839.

189. Linhart C, Davidson D, Pathmanathan S, Kamaladas T & Exley C (2020) Aluminium in brain tissue in non-neurodegenerative/non-neurodevelopmental disease: A comparison with multiple sclerosis. Exposure and Health, doi: 10.1007/s12403-020-00346-9.

188. Exley C (2020) An aluminium adjuvant in a vaccine is an acute exposure to aluminium. Journal of Trace Elements in Medicine and Biology. 57, 57-59.

187. Reichert KP, Schetinger MRC, Pillat MM, Bottari NB, Palma TV, Gutierres JM, Ulrich H, Andrade CM, Exley C & Morsch VMM (2019) Aluminium affects neural phenotype determination of embryonic neural progenitor cells. Archives of Toxicology 93, 2515-2524.

186. Martinez CS, Piagette JT, Escobar AG, Martin A, Palacios R, Pecanha FM, Vassallo DV, Exley C, Alonso MJ, Salaices M, Miguel M, Wiggers GA (2019) Egg white hydrolysate: A new putative agent to protect vascular dysfunction in rats following long term exposure to aluminium. Food and Chemical Toxicology 133, DOI: 10.1016/j.fct.2019.110799.

185. De Santis E, Shardlow E, Stellato F, Proux O, Rossi G, Exley C, Morante S (2019) X-ray absorption spectroscopy measurements of Cu-ProIAPP complexes at physiological concentrations. Condensed Matter 4, 13.

184. Martinez CS, Alterman CDC, Vera G, Márquez A, Uranga J-A, Peçanha FM, Vassallo DV, Exley C, Mello-Carpes PB, Miguel M, Wiggers GA (2019) Egg White Hydrolysate as a functional food ingredient to prevent cognitive dysfunction in rats following long-term exposure to aluminium. Scientific Reports 9, 1868.

183. Mold M, Linhart C, Gomez-Ramirez J, Villegas-Lanau A & Exley C (2019) Aluminium and amyloid-β in familial Alzheimer's disease. Journal of Alzheimer's disease, doi: 10.3233/JAD-191140.

182. Exley C, Guerriero G & Lopez X (2020) How is silicic acid transported in plants? Silicon. doi: 10.1007/s12633-019-00360-w.

181. Exley C, Guerriero G (2019) A reappraisal of biological silicification in plants. New Phytologist 223, 511-513.

180. Shardlow E, Mold M & Exley C (2019) The interactions of aluminium-based adjuvants with THP-1 macrophages in vitro: Implications for cellular survival and systemic translocation. Journal of Inorganic Biochemistry, 203, 110915. doi: 10.1016/j.jinorgbio.2019.110915.

179. Exley C (2019) An aluminium adjuvant in a vaccine is an acute exposure to aluminium. Journal of Trace Elements in Medicine and Biology. doi: 10.1016/j.jtemb.2019.09.010.

178. Exley C & Mold M (2019) Aluminium in human brain tissue: how much is too much? Journal of Biological Inorganic Chemistry. doi: 10.1007/s00775-019-01710-0.

177. Mold M, Kumar M, Chu W & Exley C (2019) Unequivocal imaging of aluminium in human cells and tissues by an improved method using morin. Histochemistry and Cell Biology. doi: 10.1007/s00418-019-01809-0.

176. Shardlow E & Exley C (2019) The size of micro-crystalline tyrosine (MCT®) influences its recognition and uptake by THP-1 macrophages in vitro. RSC Advances, 9, 24505-24518. doi: 10.1039/C9RA03831K.

175. Exley C (2019) Aluminium release during fluid warming. Anaesthesia, 74, 819-819. doi: 10.1111/anae.14673.

174. Reichert KP, Schetinger MR, Pillat MM, Bottari NB, Palma TV, Gutierres JM, Ulrich H, Andrade CM, Exley C & Morsch VMM (2019) Aluminum affects neural phenotype determination of embryonic neural progenitor cells. Archives of Toxicology. doi: 10.1007/s00204-019-02522-6.

173. Guerriero G, Deshmukh R, Sonah H, Sergeant K, Hausman JF, Lentzen E, Valle N, Siddiqui KS & Exley C (2019) Identification of the aquaporin gene family in Cannabis sativa and evidence for the accumulation of silicon in its tissues. Plant Science, 287:110167. doi: 10.1016/j.plantsci.2019.110167.

172. Mold M, Cottle J & Exley C (2019) Aluminium in brain tissue in epilepsy: A case report from Camelford. International Journal of Environmental Research and Public Health, 16(12), 2129. doi: 10.3390/ijerph16122129.

171. Mold M, Cottle J, King A & Exley C (2019) Intracellular aluminium in inflammatory and glial cells in cerebral amyloid angiopathy: A case report. International Journal of Environmental Research and Public Health, 16(8), 1459. doi: 10.3390/ijerph16081459.

170. Exley C, Guerriero G & Lopez X (2019) Silicic acid: The omniscient molecule. Science of the Total Environment, 665, 432-437. doi: 10.1016/j.scitotenv.2019.02.197.

169. Redgrove J, Rodriguez I, Mahadevan-Bava S & Exley C (2019) Prescription infant formulas are contaminated with aluminium. International Journal of Environmental Research and Public Health, 16(5), 899. doi: 10.3390/ijerph16050899.

168. Masson JD, Crépeaux G, Authier F-J, Exley C, Gherardi RK (2018) Critical analysis of reference studies on the toxicokinetics of aluminium-based adjuvants. Journal of Inorganic Biochemistry 181, 87-95.

167. Shardlow E, Mold M & Exley C (2018) Unraveling the enigma: elucidating the relationship between the physicochemical properties of aluminium-based adjuvants and their immunological mechanisms of action. Allergy, Asthma and Clinical Immunology, 14:80. doi: 10.1186/s13223-018-0305-2.

166. Asin J, Molin J, Perez M, Pinczowski P, Gimeno M, Navascues N, Muniesa A, de Blas I, Lacasta D, Fernandez A, de Pablo L, Mold M, Exley C, de Andres D, Reina R. & Lujan L (2018) Granulomas following subcutaneous injection with aluminium adjuvant-containing products in sheep. Veterinary Pathology (ePrint). doi: 10.1177/0300985818809142.

165. Guerriero G, Stokes I & Exley C (2018) Is callose required for silicification in plants? Biology Letters, 14: 20180338. doi: 10.1098/rsbl.2018.0338.

164. Shardlow E, Rao C, Sattarov R, Wu L, Fraser P & Exley C (2018) Aggregation of the diabetes-related peptide ProIAPP1-48 measured by dynamic light scattering. Journal of Trace Elements in Medicine and Biology, 51, 1-8. doi: 10.1016/j.jtemb.2018.09.001.

163. Mold M, Chmielecka A, Rodriguez M, Thom F, Linhart C, King A & Exley C (2018) Aluminium in brain tissue in multiple sclerosis. International Journal of Environmental Research and Public Health, 15(8), 1777. doi: 10.3390/ijerph15081777.

162. Mold M, Kumar M, Mirza A, Shardlow E & Exley C (2018) Intracellular tracing of amyloid vaccines through direct fluorescent labelling. Scientific Reports, 8, 2437. doi: 10.1038/s41598-018-20845-9.

161. Guerriero G, Law C, Stokes I, Moore KL & Exley C (2018) Rough and tough. How does silicic acid protect horsetail from fungal infection? Journal of Trace Elements in Medicine and Biology, 47, 45-52. doi: 10.1016/j.jtemb.2018.01.015.

160. Exley C (2017) The safety of Cervarix. Lancet Infectious Disease 17, 19-20.

159. Mujika JI, Torre GD, Formoso E, Grande-Aztatzi R, Grabowski SJ, Exley C & Lopez X (2017) Aluminium's preferential binding site in proteins: sidechain of amino acids versus backbone interactions. Journal of Inorganic Biochemistry, 181, 111-116. doi: 10.1016/j.jinorgbio.2017.10.014.

158. Mold M, Umar D, King A & Exley C (2017) Aluminium in brain tissue in autism. Journal of Trace Elements in Medicine and Biology, 46, 76-82. doi: 10.1016/j.jtemb.2017.11.012.

157. Jones K, Linhart C, Hawkins C & Exley C (2017) Urinary excretion of aluminium and silicon in secondary progressive multiple sclerosis. EBioMedicine, 26, 60-67.doi: 10.1016/j.ebiom.2017.10.028.

156. King A, Troakes C, Aizpurua M, Mirza A, Hodges A, Al-Sarraj S & Exley C (2017) Unusual neuropathological features and increased brain aluminium in a resident of Camelford, UK. Neuropathology and Applied Neurobiology, 43, 537-541. doi: 10.1111/nan.12417.

155. Exley C (2017) Aluminium should now be considered a primary etiological factor in Alzheimer's disease. Journal of Alzheimers Disease, 1, 23-25. doi: 10.3233/ADR-170010.

154. Martinez CS et al (2017) Aluminum exposure at human dietary levels promotes vascular dysfunction and increases blood pressure in rats: A concerted action of NAD(P)H oxidase and COX-2. Toxicology, 390, 10-21. doi: 10.1016/j.tox.2017.08.004.

153. Crepeaux G, Exley C, Shaw CA & Gherardi RK (2017) Scientific and ethical obligations to publish tobacco industry-funded research on nicotine delivery systems of reduced risk. Toxicology, 390, 159-159. doi: 10.1016/j.tox.2017.09.010.

152. Martinez CS et al (2017) Aluminum exposure for 60 days at human dietary levels impairs spermatogenesis and sperm quality in rats. Reproductive Toxicology, 73, 128-141. doi: 10.1016/j.reprotox.2017.08.008.

151. Linhart C et al (2017) Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study. EbioMedicine 21, 79-85. doi: 10.1016/j.ebiom.2017.06.005.

150. Masson JD, Crepeaux G, Authier FJ, Exley C & Gherardi RK (2017) Adjuvants aluminiques des vaccins: analyse critique des etudes toxicocinetiques de reference [Critical analysis of reference studies on aluminium-based adjuvants toxicokinetics]. Annales pharmaceutiques francaises 75, 245-256. doi: 10.1016/j.pharma.2017.04.004.

149. Exley C (2017) The Aluminium Age. https://www.hippocraticpost.com/mens-health/the-aluminium-age/

148. Mold M, Shardlow E & Exley C (2017) LETTER: Toward understanding the mechanisms underlying the strong adjuvant activity of aluminium salt nanoparticles. Ruwona TB, Xu H, Li X, Taylor AN, Shi Y &Cui Z. Vaccine (2016) 34, 3059-67. Vaccine (2017) 35, 1101-1101. doi: 10.1016/j.vaccine.2016.12.051.

147. Crepeaux G et al (2017) Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity. Toxicology 375, 48-57. doi: 10.1016/j.tox.201611.018.

146. Shardlow E, Mold M and Exley C (2017) From Stock Bottle to Vaccine: Elucidating the Particle Size Distributions of Aluminum Adjuvants Using Dynamic Light Scattering. Front. Chem. 4:48. doi: 10.3389/fchem.2016.00048.

145. Mirza A, King A, Troakes C & Exley C (2016) Aluminium in brain tissue in familial Alzheimer's disease. Journal of Trace Elements in Medicine and Biology. 40, 30-36. doi: http://dx.doi.org/10.1016/j.jtemb.2016.12.001.

144. Brugiére T & Exley C (2016) Callose-associated silica deposition in Arabidopsis. Journal of Trace Elements in Medicine and Biology 39, 86-90. doi: http://dx.doi.org/10.1016/j.jtemb.2016.08.005.

143. Mold M, Shardlow E & Exley C (2016) Insight into the cellular fate and toxicity of aluminium adjuvants used in clinically approved human vaccinations. Scientific Reports, 6, 31578. doi: http://dx.doi.org/10.1038/srep31578.

142. Beardmore J, Lopez X, Mujika JI & Exley C (2016) What is the mechanism of formation of hydroxyaluminosilicates? Scientific Reports 6, 30913. doi: http://dx.doi.org/10.1038/srep30913.

141. Mirza A, King A, Troakes C & Exley C (2016) The identification of aluminium in human brain tissue using lumogallion and fluorescence microscopy. Journal of Alzheimer's disease, 54, 1333-1338. doi: http://dx.doi.org/10.3233/JAD-160648.

140. Exley C (2016) The toxicity of aluminium in humans. Morphologie 100, 51-55. doi: http://dx.doi.org/10.1016/j.morpho.2015.12.003.

139. Mold M, Bunrat C, Goswami P, Roberts A, Roberts C, Taylor N, Taylor H, Wu L, Fraser PE and Exley C (2015) Further insight into the role of metals in amyloid formation by IAPP1-37 and ProIAPP1-48. Journal of Diabetes Research & Clinical Metabolism, 4,4.

138. Crépeaux G, Eidi H, David M-O, Tzavara E, Giros B, Exley C, Curmi PA, Shaw CA, Gherardi RK and Cadusseau J (2015) Highly delayed systemic translocation of aluminium-based adjuvant in CD1 mice following intramuscular injections. Journal of Inorganic Biochemistry, 152, 199-205. doi: http://dx.doi.org/10.1016/j.jinorgbio.2015.07.004.

137. Exley C (2015) Guest editorial for the Special Issue from the Eleventh Keele Meeting on Aluminium. Journal of Inorganic Biochemistry, 152:138. doi: http://dx.doi.org/10.1016/j.jinorgbio.2015.11.019

136. Exley C (2015) A possible mechanism of biological silicification in plants. Frontiers in Plant Science, 6:853. doi: 10.3389/fpls.2015.00853.

135. Exley C, Rotheray E and Goulson D (2015) Bumblebee pupae contain high levels of aluminium. PLOS ONE 10 (6); e0127665. doi:10.1371/journal.pone.0127665.

134. Exley C and Mold MJ (2015) The binding, transport and fate of aluminium in biological cells. Journal of Trace Elements in Medicine and Biology 30, 90-95.

133. Exley C (2014) Why industry propaganda and political interference cannot disguise the inevitable role played by human exposure to aluminium in neurodegenerative diseases, including Alzheimer’s disease. Frontiers in Neurology 5:212. doi: 10.3389/fneur.2014.00212.

132. Klein JP, Mold M, Mery L, Cottier M and Exley C (2014) Aluminium content of human semen: Implications for semen quality. Reproductive Toxicology, 50, 43-48.

131. Mold M, Eriksson H, Siesjö P, Darabi A, Shardlow E and Exley C (2014) Unequivocal identification of intracellular aluminium adjuvant in a monocytic THP-1 cell line. Scientific Reports, 4, 6287.

130. Exley C (2014) Aluminium. In Binding, Transport and Storage of Metal Ions in Biological Cells. (Ed. W Maret and AG Wedd) Royal Society of Chemistry, Cambridge, 833-842.

129. Exley C and Sjöberg S (2014) Silicon species in seawater. Spectrochimica Acta Part A, 117, 820-821.

128. Exley C (2014) What is the risk of aluminium as a neurotoxin? Expert Review of Neurotherapeutics, 14, 589-591.

127. Everett J, Cespedes E, Shelford LR, Exley C, Collingwood JF, Dobson J, van der Laan G, Jenkins CA, Arenholz E and Telling ND (2014) Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer’s disease peptide b-amyloid. Journal of the Royal Society Interface 11, 20140165.

126. Everett J, Cespedes E, Shelford LR, Exley C, Collingwood JF, Dobson J, van der Laan G, Jenkins CA, Arenholz E and Telling ND (2014) Evidence of redox-active iron formation following aggregation of ferrihydrite and the Alzheimer’s disease peptide b-amyloid. Inorganic Chemistry 53, 2803-2809.

125. Exley C and Vickers T (2014) Elevated brain aluminium and early onset Alzheimer’s disease in an individual occupationally exposed to aluminium: a case report. Journal of Medical Case Reports 8,41.

124. Exley C (2014) Aluminium adjuvants and adverse events in sub-cutaneous allergy immunotherapy. Allergy, Asthma and Clinical Immunology 10, 4.

123. Minshall C, Nadal J and Exley C (2014) Aluminium in human sweat. Journal of Trace Elements in Medicine and Biology 28, 87-88. HEA

122. Darbre PD, Mannello F and Exley C (2013) Aluminium and breast cancer: Sources of exposure, tissue measurements and mechanisms of toxicological actions on breast biology. Journal of Inorganic Biochemistry 128, 257-261.

121. Chuchu N, Patel B, Sebastian B, Exley C (2013). The aluminium content of infant formulas remains too high. BMC Pediatrics. 13:162

120. Exley (2013). Human exposure to aluminium. Environmental Science: Processes & Impacts. 15, 1807-1816.

119. House E, Polwart A, Darbre P, Barr L, Metaxas G, Exley C (2013) The aluminium content of breast tissue taken from women with breast cancer. Journal of Trace Elements in Medicine and Biology. 27, 257-266.

118. Ohlsson L, Exley C, Darabi A, Sandén E, Siesjö P, Eriksson H (2013) Aluminium based adjuvants and their effects on mitochondria and lysosomes of phagocytosing cells. Journal of Inorganic Biochemistry 128, 229-236.

117. Buffoli B, Foglio E, Borsani E, Exley C, Rezzani R, Rodella LF (2013) Silicic acid in drinking water prevents age-related alterations in the endothelium-dependent vascular relaxation modulating eNOS and AQP1 expression in experimental mice: An immunohistochemical study. Acta Histochemica 115, 418-424.

116. Khan Z, Combadière C, Authier FJ, Itier V, Lux F, Exley C, Mahrouf-Yorgov M, Decrouy X, Moretto P, Tillement O, Gherardi RK, and Cadusseau J (2013) Slow CCL2-dependent translocation of biopersistent particles from muscle to brain. BMC Medicine 11:99.

115. Mold M, Ouro-Gnao L, Wieckowski B.M. & Exley C (2013) Copper prevents amyloid-β1–42 from forming amyloid fibrils under near-physiological conditions in vitro, Scientific Reports, 3 DOI: 10.1038/srep01256

114. Mold M, Shrive AK and Exley C (2012) Serum amyloid P component accelerates the formation and enhances the stability of amyloid fibrils in a physiologically significant under-saturated solution of Aß42. Journal of Alzheimer’s Disease 29, 875-881.

113. Ruipérez F, Mujika JI, Ugalde JM, Exley C, Lopez X (2012) Pro-oxidant activity of aluminium: promoting the Fenton reaction by reducing Fe(III) to Fe(II). Journal of Inorganic Biochemistry 117, 118-123.

112. Exley C and House ER (2012) Aluminium in the human brain. In Metal Ions in Neurological Systems (Linert W. & Kozlowski H. Eds) Springer pp95-102.

111. Davenward S, Bentham P, Wright J, Crome P, Job, D, Polwart A and Exley C (2012) Silicon-rich mineral water as a non-invasive test of the ‘aluminium hypothesis’ in Alzheimer’s disease. Journal of Alzheimer’s Disease (In the press.).

110. Foglio E, Buffoli B, Exley C, Rezzani R and Rodella LF (2012) Regular consumption of a silicic acid-rich water prevents aluminium-induced alterations of nitrergic neurons in mouse brain: histochemical and immunohistochemical studies. Histology and Histopathology 27, 1055-1066.

109. Exley C, Mold M, Shardlow E, Shuker B, Ikpe B, Wu L and Fraser PE (2012) Copper is a potent inhibitor of the propensity for human ProIAPP1-48 to form amyloid fibrils in vitro. Journal of Diabetes Research and Clinical Medicine 1, 3 (26th May 2012).

108. Exley C, House E, Polwart A and Esiri MM (2012) Brain burdens of aluminium, iron and copper and their relationships with amyloid beta pathology in 60 human brains. Journal of Alzheimer’s Disease 31, 725-730.

107. Exley C (2012) The coordination chemistry of aluminium in neurodegenerative disease. Coordination Chemistry Reviews 256, 2142-2146.

106. Exley C (2012) When an aluminium adjuvant is not an aluminium adjuvant used in human vaccination programmes. Vaccine 30(12), 2042.

105. Exley C (2012) Aluminium in biological systems. Encyclopedia of Metalloproteins (Kretsinger RH, Permyakov EA, Uversky VN eds.) Springer Science, 1300 pages, ISBN 978-1-4614-1532-9 (hardcover) / 978-1-4614-1533-6 (e-book) / 978-1-4614-1534-3 (hardcover plus e-book).

104. House E, Esiri M, Forster G, Ince PG and Exley C (2012) Aluminium, iron and copper in human brain tissues donated to the medical research council’s cognitive function and ageing study. Metallomics 4, 56-65.

103. Exley C (2012) Elucidating aluminium’s exposome. Current Inorganic Chemistry 2(1), 3-7.

102. Exley C (2012) Reflections upon and recent insight into the mechanism of formation of hydroxyaluminosilicates and the therapeutic potential of silicic acid. Coordination Chemistry Reviews 256, 82-88.

101. Law C and Exley C (2011) New insight into silica deposition in horsetail (Equisetum arvense). BMC Plant Biology 11, 112.

100. Mujika JI, Ruiperez F, Infante I, Ugalde JM, Exley C, Lopez X (2011) Pro-oxidant activity of aluminium: Stabilisation of the aluminium superoxide radical ion. The Journal of Physical Chemistry A 115, 6717-6723.

99. Exley C (2011) Aluminium-based adjuvants should not be used as placebos in clinical trials. Vaccine 29, 9289.

98. House E, Jones K and Exley C (2011) Spherulites in human brain tissue are composed of beta sheets of amyloid and resemble senile plaques. Journal of Alzheimer’s Disease 25, 43-46.

97. Exley C and House E (2011) Aluminium in the human brain. Monatshefte für Chemie - Chemical Monthly 142, 357-363.

96. Burrell S-A M and Exley C (2010) There is (still) too much aluminium in infant formulas. BMC Pediatrics 10:63.

95. Exley C, House E, Patel T, Wu L & Fraser PE (2010) Human pro-islet amyloid polypeptide (ProIAPP1-48) forms amyloid fibrils and amyloid spherulites in vitro. Journal of Inorganic Biochemistry 104, 1125-1129.

94. Exley C, House E, Collingwood JF, Davidson M, Cannon D & Donald AM (2010) Spherulites of Ab42 in vitro and in Alzheimer’s disease. Journal of Alzheimer’s Disease 20, 1159-1165.

93. Exley C, Siesjö P & Eriksson H (2010) The immunobiology of aluminium adjuvants: how do they really work? Trends in Immunology 31, 103-109.

92. Dobrzynski D and Exley C (2010) Solubility control and therapeutic potential of silicon in curative mineral waters of the Sudetes Mountains, Poland. Acta Balneologica 52, 142-150.

91. House E, Mold M, Collingwood J, Baldwin A, Goodwin S & Exley C (2009) Copper abolishes the β-sheet secondary structure of pre-formed amyloid fibrils of Amyloid-β42. Journal of Alzheimer’s Disease 18, 811-817.

90. Exley C (2009) Darwin, natural selection and the biological essentiality of aluminium and silicon. Trends in Biochemical Sciences 34, 589-593.

89. Exley (2009) What happened to the epidemic in new variant Creutzfeldt-Jakob disease? Medical Hypotheses 72, 621-622.

88. Exley C (2009) Silicon in Life: Whither Biological Silicifcation? In; Biosilica in Evolution, Morphogenesis, and Nanobiotechnology (Eds. WEG Müller, MA Grachev), Progress in Molecular and Subcellular Biology, Marine Molecular Biotechnology, 47, p 173-184. BOOK CHAPTER

87. Exley C (2009) Aluminium and Medicine. In; Molecular and Supramolecular Bioinorganic Chemistry: Applications in Medical Sciences. (Ed. ALR Merce, J Felcman, MAL Recio), Nova Science Publishers Inc. New York, p 45-68. BOOK CHAPTER

86. Exley C (2009) Silicon and bone. Bone 44, 1018.

85. Beardmore J & Exley C (2009) Towards a model of non-equilibrium binding of metal ions in biological systems. Journal of Inorganic Biochemistry 103, 205-209.

84. Exley C, Swarbrick L, Gheradi R & Authier J-F (2009) A role for the body burden of aluminium in vaccine-associated macrophagic myofasciitis and chronic fatigue syndrome. Medical Hypotheses 72, 135-139.

83. Maingon R, Khela A, Sampson C, Ward R, Walker K & Exley C (2008) Aluminium: a natural adjuvant in Leishmania transmission via sand flies? Transactions of the Royal Society of Tropical Medicine and Hygiene 102, 1140-1142.

82. Exley C (2008) Comment on “Avoidance of aluminium toxicity in freshwater snails involves intracellular silicon-aluminium biointeraction”. Environmental Science & Technology 42, 5374.

81. Ward B, Walker K & Exley C (2008) Copper(II) inhibits the formation of amylin amyloid in vitro. Journal of Inorganic Biochemistry 102, 371-375.

80. Exley C (2007) The solubility of hydroxyaluminosilicates and the biological availability of aluminium. In; Thermodynamics, Solubility and Environmental Issues (Ed. Letcher TM), Elsevier Science, Amsterdam, The Netherlands. p 315-325. BOOK CHAPTER

79. Quintal-Tun F, Muno-Sanchez JA, Ramos Diaz A, Escamilla-Bencomo A, Martinez-Estevez M, Exley C, Hernandez-Sotomayor SMT (2007) Aluminium-induced phospholipid signal transduction pathway in Coffea arabica suspension cells and its amelioration by silicic acid. Journal of Inorganic Biochemistry 101, 362-369.

78. Beardmore J, Rugg G & Exley C (2007) A systems biology approach to the blood-aluminium problem: The application and testing of a computational model. Journal of Inorganic Biochemistry 101, 1187-1191.

77. Exley C, Charles LM, Barr L, Martin C, Polwart A & Darbre PD (2007) Aluminium in human breast tissue. Journal of Inorganic Biochemistry 101, 1344-1346.

76. Exley C, Ahmed U, Polwart A & Bloor RN (2007) Elevated urinary aluminium in current and past users of illicit heroin. Addiction Biology 12, 197-199.

75. Exley C, Beardmore J & Rugg G (2007) A computational approach to the blood-aluminium problem? International Journal of Quantum Chemistry 107, 275-278.

74. Exley C (2007) Aluminium, tau and Alzheimer’s disease. Journal of Alzheimer’s Disease 12, 313-315.

73. Nicholson S & Exley C (2007) Aluminium: A potential pro-oxidant in sunscreens/sunblocks? Free Radical Biology and Medicine 43, 1216-1217.

72. Exley C (2007) Organosilicon therapy in Alzheimer’s disease? Journal of Alzheimer’s Disease 11, 301-302.

71. Exley C (2006) A vexing commentary on the important issue of aluminium and Alzheimer’s disease. Journal of Alzheimer’s Disease 10, 451-452.

70. Exley C (2006) Funding should recognize outcome, not income. Nature 440, 1112.

69. Exley C (2006) Aluminium-adsorbed vaccines. The Lancet Infectious Diseases 6, 189.

68. Strekopytov S, Jarry E & Exley C (2006) Further insight into the mechanism of formation of hydroxyaluminosilicates. Polyhedron 25, 3399-3404.

67. Exley C, Korchazhkina O, Job D, Strekopytov S, Polwart A & Crome P (2006) Non-invasive therapy to reduce the body burden of aluminium in Alzheimer’s disease. Journal of Alzheimer’s Disease 10, 17-24.

66. Exley C (2006) Aluminium and iron, but neither copper nor zinc, are key to the precipitation of b-sheets of Ab42 in senile plaque cores in Alzheimer’s disease. Journal of Alzheimer’s Disease 10, 173-177.

65. Exley C & Esiri M (2006) Severe cerebral congophilic angiopathy coincident with increased brain aluminium in a resident of Camelford, Cornwall, UK. Journal of Neurology Neurosurgery and Psychiatry 77, 877-879.

64. Khan A, Dobson J & Exley C (2006) The redox cycling of iron by Ab42. Free Radical Biology and Medicine 40, 557-569.

63. Exley C, Mamutse G, Korchazhkina O, Pye E, Strekopytov S, Polwart A & Hawkins C (2006) Elevated urinary excretion of aluminium and iron in multiple sclerosis. Multiple Sclerosis 12, 533-540.

62. Strekopytov S & Exley C (2006) Thermal analyses of aluminium hydroxide and hydroxyaluminosilicates. Polyhedron 25, 1707-1713.

61. Khan A, Ashcroft AE, Higenell V, Korchazhkina OV & Exley C (2005) Metals accelerate the formation and direct the structure of amyloid fibrils of NAC. Journal of Inorganic Biochemistry 99, 1920-1927.

60. Exley C, Begum A, Woolley MP & Bloor RN (2006) Aluminium in tobacco and cannabis and smoking-related disease. American Journal of Medicine 119, 276.e9-276.ell.

59. Exley C (2005)The Aluminium-Amyloid Cascade Hypothesis and Alzheimer's Disease. In: Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta. Subcellular Biochemistry 38, (Eds. Harris R & Fahrenholz F) p 225-234. BOOK CHAPTER

58. Strekopytov S & Exley C (2005) The formation, precipitation and structural characterisation of hydroxyaluminosilicates formed in the presence of fluoride and phosphate. Polyhedron 24, 1585-1592.

57. Exley C (2005) Comment on “The biological behaviour and bioavailability of aluminium in man” by N.D. Priest, JEM, 2004, 6, 375. Journal of Environmental Monitoring 7, 640.

56. Exley C (2004) Aluminum in antiperspirants: More than just skin deep. American Journal of Medicine 117, 969-970.

55. Exley C (2004) Aluminium-containing DTP vaccines. The Lancet Infectious Diseases 4, 324.

54. Schneider C, Doucet F, Strekopytov S & Exley C (2004) The solubility of an hydroxyaluminosilicate. Polyhedron 23, 3185-3191.

53. Khan A, Ashcroft AE, Korchazhkina OV & Exley C (2004) Metal-mediated formation of fibrillar ABri amyloid. Journal of Inorganic Biochemistry 98, 2006-2010.

52. House E, Collingwood J, Khan A, Korchazhkina O, Berthon G & Exley C (2004) Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of A[beta]42 in a manner which may have consequences for metal chelation therapy in Alzheimer's disease. Journal of Alzheimers Disease 6, 291-301.

51. Exley C (2004) The prooxidant activity of aluminium. Free Radical Biology and Medicine 36, 380-387.

50. Exley C (2003) A biogeochemical cycle for aluminium? Journal of Inorganic Biochemistry, 97, 1-7.

49. Korchazhkina OV, Exley C & Spencer SA (2003) Measurement by RP-HPLC of malondialdehyde in normal human urine following derivitization with 2,4-dinitrophenylhydrazine. Journal of Chromatography B, 794, 353-362.

48. Korchazhkina OV, Ashcroft AE, Croom J & Exley C (2003) Does either the gastrointestinal peptide PYY or the neuropeptide NPY bind aluminium? Journal of Inorganic Biochemistry 94, 372-380.

47. Korchazhkina OV, Ashcroft AE, Kiss T & Exley C (2002) The degradation of Ab25-35 by the serine protease plasmin is inhibited by aluminium. Journal of Alzheimer’s Disease 4, 357-367.

46. Exley C, Schneider C & Doucet FJ (2002) The reaction of aluminium with silicic acid in acidic solution: An important mechanism in controlling the biological availability of aluminium ? Coordination Chemistry Reviews 228, 127-135.

45. Exley C (2001) Aluminium and Alzheimer's disease. Journal of Alzheimer’s Disease 3, 551-552.

44. Exley C (Editor) (2001) Aluminium and Alzheimer’s Disease: The Science that Describes the Link. Elsevier Science, Amsterdam, The Netherlands. 441p. BOOK EDITOR

43. Exley C & Korchazhkina O (2001) The association of aluminium and b amyloid in Alzheimer’s disease. In; Aluminium and Alzheimer’s Disease: The Science that Describes the Link (Editor; C Exley) Elsevier Science, Amsterdam, The Netherlands. p421-433. BOOK CHAPTER

42. Exley C (2001) Preface. Why is research into aluminium and life important ? In; Aluminium and Alzheimer’s Disease: The Science that Describes the Link (Editor; C Exley) Elsevier Science, Amsterdam, The Netherlands. P V-VIII. BOOK CHAPTER

41. Exley C & Korchazhkina OV (2001) Plasmin cleaves A[beta]42 in vitro and prevents its aggregation into b-pleated sheet structures. Neuroreport 12, 2967-2970.

40. Doucet FJ, Rotov ME & Exley C (2001) Direct and indirect identification of the formation of hydroxyaluminosilicates (HAS) in acidic solutions. Journal of Inorganic Biochemistry 87, 71-79.

39. Schneider C & Exley C (2001) Silicic acid (Si(OH)4) is a significant influence upon the atomic absorption signal of aluminium measured by graphite furnace atomic absorption spectrometry (GFAAS). Journal of Inorganic Biochemistry 87, 45-50.

38. Exley C & Korchazhkina O (2001) Promotion of formation of amyloid fibrils by aluminium adenosine triphosphate (AlATP). Journal of Inorganic Biochemistry 84, 215-224.

37. Doucet FJ, Schneider C, Bones SJ, Kretchmer A, Moss I, Tekely P & Exley C (2001) The formation of hydroxyaluminosilicates of geochemical and biological significance. Geochimica Cosmochimica Acta 65, 2461-2467.

36. Exley C (2000) Avoidance of aluminium by rainbow trout. Environmental Toxicology and Chemistry 19, 933-939.

35. Korchazhkina OV, Wright G & Exley C (1999) No effect of aluminium upon the hydrolysis of ATP in the coronary circulation of the isolated working rat heart. Journal of Inorganic Biochemistry 76, 121-126.

34. Exley C (1999) A molecular mechanism of aluminium-induced Alzheimer's disease? Journal of Inorganic Biochemistry 76, 133-140.

33. Korchazhkina O, Wright G & Exley C (1999) Intravascular ATP and coronary vasodilation in the isolated working rat heart. British Journal of Pharmacology 127, 701-708.

32. Exley C (1998) The precipitation of mucin by aluminium. Journal of Inorganic Biochemistry 70, 195-206.

31. Korchazhkina O, Wright G & Exley C (1998) Action of Al-ATP on the isolated working rat heart. Journal of Inorganic Biochemistry 69, 153-158.

30. Exley C (1998) Silicon in life: A bioinorganic solution to bioorganic essentiality. Journal of Inorganic Biochemistry 69, 139-144.

29. Exley C (1998) Does antiperspirant use increase the risk of aluminium-related disease, including Alzheimer's disease ? Molecular Medicine Today 4, 107-109.

28. Savory J, Exley C, Forbes WF, Huang Y, Joshi JG, Kruck T, McLachlan DRC & Wakayama I (1997) Can the controversy of the role of aluminium in Alzheimer's disease be resolved? What are the suggested approaches to this controversy and methodological issues to be considered? In; Research Issues in Aluminium Toxicity (Editors; RA Yokel & MS Golub) Taylor & Francis, Washington DC, USA. p185-206. BOOK CHAPTER

27. Harris WR, Berthon G, Day JP, Exley C, Flaten TP, Forbes WF, Kiss T, Orvig C & Zatta PF (1997) Speciation of aluminium in biological systems. In; Research Issues in Aluminium Toxicity (Editors; RA Yokel & MS Golub) Taylor & Francis, Washington DC, USA. p91-116. BOOK CHAPTER

26. Exley C, Burgess E, Day JP, Jeffery EH, Melethil S & Yokel RA (1997) Aluminium toxicokinetics. In; Research Issues in Aluminium Toxicity (Editors; RA Yokel & MS Golub) Taylor & Francis, Washington DC, USA. p117-132. BOOK CHAPTER

25. Exley C, Pinnegar JK & Taylor H (1997) Hydroxyaluminosilicates and acute aluminium toxicity in fish. Journal of Theoretical Biology 189, 133-139.

24. Exley C (1997) ATP-promoted amyloidosis of an amyloid beta peptide. Neuroreport 8, 3411-3414.

23. Savory J, Exley C, Forbes WF, Huang Y, Joshi JG, Kruck T, McLachlan DRC & Wakayama I (1996) Can the controversy of the role of aluminium in Alzheimer's disease be resolved. What are the suggested approaches to this controversy and methodological issues to be considered. Journal of Toxicology and Environmental Health 48, 615-635.

22. Harris WR, Berthon G, Day JP, Exley C, Flaten TP, Forbes WF, Kiss T, Orvig C & Zatta PF (1996) Speciation of aluminium in biological systems. Journal of Toxicology and Environmental Health 48, 543-568.

21. Exley C, Burgess E, Day JP, Jeffery EH, Melethil S & Yokel RA (1996) Aluminium toxicokinetics. Journal of Toxicology and Environmental Health 48, 569-584.

20. Exley C, Wicks AJ, Hubert RB & Birchall JD (1996) Kinetic constraints in acute aluminium toxicity in the rainbow trout (Oncorhynchus mykiss). Journal of Theoretical Biology 179, 25-31.

19. Exley C & Birchall JD (1996) Biological availability of aluminium in commercial ATP. Journal of Inorganic Biochemistry 63, 241-252.

18. Exley C (1996) Aluminium in the brain and heart of the rainbow trout. Journal of Fish Biology 48, 706-713.

17. Exley C (1996) Amyloid, aluminium and the aetiology of Alzheimer's disease. Medical Journal of Australia 164, 252-253.

16. Exley C (1996) In vitro toxicity of beta-amyloid. Biochemical Journal 314, 709.

15. Exley C & Birchall JD (1996) Silicic acid and the biological availability of aluminium. European Journal of Soil Science 47, 137.

14. Exley C & Birchall JD (1995) Comment on " An assessment of complex formation between aluminium and silicic acid in acidic solutions". Geochimica Cosmochimica Acta 59, 5, 1017-1018.

13. Exley C, Schley L, Murray S, Hackney CM & Birchall JD (1995) Aluminium, β-amyloid and non-enzymatic glycosylation. FEBS Letters, 364, 182-184.

12. Exley C, Price NC & Birchall JD (1994) Aluminium inhibition of hexokinase activity in vitro: a study in biological availability. Journal of Inorganic Biochemistry 54, 297-304.

11. Exley C, Wicks AJ, Hubert RB & Birchall JD (1994) Polynuclear aluminium and acute aluminium toxicity in the fish. Journal of Theoretical Biology 167, 415-416.

10. Exley C & Birchall JD (1993) Aluminium and Alzheimer's Disease. Age and Ageing 22, 391-392.

9. Exley C, Price NC, Kelly SM & Birchall JD (1993) An interaction of β-amyloid with aluminium in vitro. FEBS Letters, 324, 293-295.

8. Exley C, Tollervey A, Gray G, Roberts S & Birchall JD (1993) Silicon, aluminium and the biological availability of phosphorus in algae. Proceedings of the Royal Society of London Series B 253, 93-99.

7. Exley C & Birchall JD (1993) A mechanism of hydroxyaluminosilicate formation. Polyhedron, 12, 1007-1017.

6. Exley C & Birchall JD (1992) The cellular toxicity of aluminium. Journal of Theoretical Biology, 159, 83-98.

5. Exley C & Birchall JD (1992) Hydroxyaluminosilicate formation in solutions of low total aluminium concentration. Polyhedron, 11, 1901-1907.

4. Birchall JD & Exley C (1992) Silicon and the bioavailability of aluminium. Metal Compounds in Environment and Life, 4, 411-418.

3. Exley C, Chappell JS & Birchall JD (1991) A mechanism for acute aluminium toxicity in fish. Journal of Theoretical Biology, 151, 417-428.

2. Birchall JD, Exley C, Chappell JS & Phillips MJ (1989) Acute toxicity of aluminium to fish eliminated in silicon-rich acid waters Nature, 338, 146-148.

1. Exley C & Phillips MJ (1988) Acid rain: Implications for the farming of salmonids. Recent Advances in Aquaculture, 3, 225-341. BOOK CHAPTER